5-Hydroxy-1,4-naphthoquinone , 10mMinDMSO , 481-39-0

Synonym(s):
5-Hydroxy-1,4-naphthlenedione, 5-Hydroxy- p-naphthoquinone;5-Hydroxy-1,4-naphthoquinone;Juglone;Juglone - CAS 481-39-0 - Calbiochem

CAS NO.：481-39-0

Empirical Formula: C10H6O3

Molecular Weight: 174.15

MDL number: MFCD00001684

EINECS: 207-567-5

PRODUCT Properties

• Melting point: 161-163 °C (lit.)
• Boiling point: 265.11°C (rough estimate)
• Density: 1.2346 (rough estimate)
• refractive index: 1.5036 (estimate)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: DMSO: 10 mg/ml; Ethanol: 10 mg/ml
• pka: 6.59±0.20(Predicted)
• form: Crystalline Powder
• color: Orange to brown
• Water Solubility: SOLUBLE IN HOT WATER
• Sensitive: Light Sensitive
• Merck: 14,5269
• BRN: 1909764
• LogP: 1.920
• CAS DataBase Reference: 481-39-0(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Naphthalenedione, 5-hydroxy-(481-39-0)
• EPA Substance Registry System: 1,4-Naphthalenedione, 5-hydroxy- (481-39-0)

Description and Uses

Juglone (5-hydroxynapthoquinone), is found in the leaves and other parts of walnut, hickory and pecan (1,2). Juglone is synthesized from isochorismic acid (a product of the shikimic acid pathway) and 2-oxo-glutaric acid (3). In plant tissue juglone exists as a free compound or as a glycoside (3,4). Action of a glucosidase releases 1,4,5-trihydroxynapthalene, which is then oxidized to juglone (3,4).

antineoplastic, antifungal, antioxidant, Pin 1 inhibitor

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P264-P270-P301+P310-P405-P501
• Hazard Codes: T
• Risk Statements: 25-36/37/38
• Safety Statements: 22-26-36/37/39-45-37/39-28A
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: QJ5775000
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29146990
• Toxicity: LD50 oral in rat: 112mg/kg