Lumefantrine , 10mMinDMSO , 82186-77-4

Synonym(s):
(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-9H-fluorene-4-methanol;Benflumetol;CPG-56695;Lumefantrine

CAS NO.：82186-77-4

Empirical Formula: C30H32Cl3NO

Molecular Weight: 528.94

MDL number: MFCD05662268

EINECS: 617-303-4

PRODUCT Properties

• Melting point: 129-131°C
• Boiling point: 642.5±55.0 °C(Predicted)
• Density: 1.252
• storage temp.: 15-25°C
• solubility: DMSO: ≥20mg/mL
• pka: 13.44±0.20(Predicted)
• form: powder
• color: yellow
• Merck: 14,5597
• InChIKey: DYLGFOYVTXJFJP-MYYYXRDXSA-N
• SMILES: C12C(C(CN(CCCC)CCCC)O)=CC(Cl)=CC=1/C(=C\C1C=CC(Cl)=CC=1)/C1C=C(Cl)C=CC2=1
• CAS DataBase Reference: 82186-77-4(CAS DataBase Reference)

Description and Uses

Lumefantrine is an antimalarial drug that is used in combination with artemether . The pairing of lumefantrine and artemether is a major form of oral artemisinin combination therapy used against uncomplicated P. falciparum malaria. Lumefantrine also blocks the rapidly activating delayed-rectifier potassium channel (I_Kr; IC₅₀ = 8.1 μM).

A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• WGK Germany: 3
• HS Code: 29221950
• Hazardous Substances Data: 82186-77-4(Hazardous Substances Data)