A7633858
LDK378 , 10mMinDMSO , 1032900-25-6
CAS NO.：1032900-25-6
Empirical Formula: C28H36ClN5O3S
Molecular Weight: 558.14
MDL number: MFCD26142648
EINECS: 811-457-8
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 173-175°C |
| Boiling point: | 720.7±70.0 °C(Predicted) |
| Density | 1.251±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 10.16±0.10(Predicted) |
| form | Off-white solid. |
| color | White to Off-White |
| InChIKey | VERWOWGGCGHDQE-UHFFFAOYSA-N |
| SMILES | C1(NC2=CC(C)=C(C3CCNCC3)C=C2OC(C)C)=NC=C(Cl)C(NC2=CC=CC=C2S(C(C)C)(=O)=O)=N1 |
Description and Uses
Ceritinib (previously LDK378l, brand name Zykadia; Novartis Pharmaceuticals) is an oral small molecule tyrosine kinase inhibitor of ALK [87]. Preclinical studies suggested that it would inhibit ROS1 as well [88, 89].
5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine, is a Anaplastic lymphoma kinase (ALK) inhibitor.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H320-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
