Flubendazole , 2mMinDMSO , 31430-15-6
Synonym(s):
Flubendazol;Flubendazole;Flumoxanal;Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
CAS NO.：31430-15-6
Empirical Formula: C16H12FN3O3
Molecular Weight: 313.28
MDL number: MFCD00871999
EINECS: 250-624-4
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 290°C |
| Density | 1.3720 (estimate) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, in alcohol and in methylene chloride |
| pka | 10.66±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| Merck | 14,4118 |
| Major Application | forensics and toxicology pharmaceutical (small molecule) |
| InChI | 1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22) |
| InChIKey | CPEUVMUXAHMANV-UHFFFAOYSA-N |
| SMILES | COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3ccc(F)cc3 |
| CAS DataBase Reference | 31430-15-6(CAS DataBase Reference) |
Description and Uses
Flubendazole is a benzimidazole carbamate anthelmintic. It completely eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. Flubendazole inhibits mammalian tubulin polymerization (IC50 = 2.5 μM) and inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin (IC50 = 0.17 μM). Flubendazole also inhibits the proliferation of BT-549, SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells (IC50s = 0.72, 1.51, 1.75, and 5.51 μM, respectively) and reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at a dose of 25 mg/kg.
An insectocidal agent.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Risk Statements | 22 |
| Safety Statements | 44 |
| WGK Germany | 2 |
| RTECS | DD6497500 |
| HS Code | 29339900 |
| Storage Class | 10 - Combustible liquids |
| Toxicity | LD50 in mice, rats, guinea pigs (mg/kg): >2560 orally (Thienpont) |
