A7655958
MG-132 , 10mMinDMSO , 133407-82-6
Synonym(s):
Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, Proteasome Inhibitor XI;MG-132;Proteasome Inhibitor XI, Z-Leu-Leu-Leu-CHO, Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal;Z-Leu-Leu-Leu-al
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB605.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 80-84℃ (DEC.) |
| alpha | -61～-67° |
| Boiling point: | 682.0±55.0 °C(Predicted) |
| Density | 1.073 |
| Flash point: | 366℃ |
| storage temp. | -20°C |
| solubility | methanol: 1 mg/mL |
| form | solid film |
| pka | 11.14±0.46(Predicted) |
| color | White |
| Water Solubility | Soluble in ethanol, chloroform, methanol, water. |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week. |
| InChIKey | TZYWCYJVHRLUCT-VABKMULXSA-N |
| SMILES | C(N)(=O)[C@H](CC(C)C)N(C(=O)[C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)[C@H](C=O)CC(C)C |
Description and Uses
MG-132 (133407-82-6) is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate).1 Also inhibits calpain (IC50=1.25 μM).1 Suppresses gastric cancer cell proliferation and induces macro-autophagy.2 Activates stress kinases and induces Hsp72.3 Induces neurite outgrowth.1 MG-132 blocks NFκB activation by blocking IκB proteolysis (IC50=3 μM).4 Cell permeable.
A proteasome and NF-κB inhibitor.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P280 |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29242990 |
