PRODUCT Properties
| Melting point: | 201-204 °C |
| Boiling point: | 278.08°C (rough estimate) |
| Density | 1.3840 (rough estimate) |
| refractive index | 1.5690 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | ethanol: 50 mg/mL, clear |
| pka | 8.04±0.23(Predicted) |
| form | Crystalline Powder |
| color | White to slightly beige |
| Water Solubility | SOLUBLE IN HOT WATER |
| Merck | 14,4345 |
| BRN | 2113180 |
| InChI | 1S/C8H8O5/c1-13-8(12)4-2-5(9)7(11)6(10)3-4/h2-3,9-11H,1H3 |
| InChIKey | FBSFWRHWHYMIOG-UHFFFAOYSA-N |
| SMILES | COC(=O)c1cc(O)c(O)c(O)c1 |
| LogP | 0.860 |
| CAS DataBase Reference | 99-24-1(CAS DataBase Reference) |
| EPA Substance Registry System | Benzoic acid, 3,4,5-trihydroxy-, methyl ester (99-24-1) |
Description and Uses
Methyl gallate is a phenol that has been found in Meliaceae and has diverse biological activities. It reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells when used at a concentration of 50 μM. Methyl gallate is active against V. cholerae in vitro (MIC = 32 μg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice when administered at doses of 50, 100, and 200 mg/kg. It reduces tumor growth and decreases the number of intratumor CD25+Foxp3high regulatory T cells (Tregs) in an EL-4 model of murine lymphoma. Methyl gallate (0.7, 7, and 70 mg/kg) reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis.
Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P301+P312+P330-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38-43 |
| Safety Statements | 26-36/37-24/25 |
| WGK Germany | 3 |
| RTECS | LW8000000 |
| TSCA | TSCA listed |
| HS Code | 29182900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
