Tetracycline hydrochloride , USP level , 64-75-5

Synonym(s):
Tetracycline, Hydrochloride - CAS 64-75-5 - Calbiochem

CAS NO.：64-75-5

Empirical Formula: C22H25ClN2O8

Molecular Weight: 480.9

MDL number: MFCD00078142

EINECS: 200-593-8

PRODUCT Properties

• Melting point: 220-223 °C(lit.)
• alpha: -252 º (c=0.5, H2O)
• refractive index: -253 ° (C=0.5, 0.1mol/L HCl)
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: H₂O: 10 mg/mL as a stock solution. Stock solutions should be filtered sterilized and stored at −20°C. Stable at 37°C for 4 days.
• form: powder
• color: faint yellow to yellow
• PH: pH(10g/l, 25℃) : 1.8～3.0
• optical activity: [α]/D -255 to 240° (Specific rotation )
• Water Solubility: 50 g/L
• Sensitive: Air & Light Sensitive
• Merck: 14,9196
• BRN: 3844873
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: XMEVHPAGJVLHIG-FMZCEJRJSA-N
• CAS DataBase Reference: 64-75-5(CAS DataBase Reference)
• EPA Substance Registry System: Tetracycline hydrochloride (64-75-5)

Description and Uses

Tetracycline is a broad-spectrum antibiotic that prevents bacterial growth by inhibiting protein synthesis. It binds to a single site in the 30S ribosomal subunit which prevents attachment of aminoacyl tRNA to the ribosomal acceptor site. It is used in cell biology as a selective agent in cell culture systems. Tetracycline is toxic to prokaryotic and eukaryotic cells and selects for cells harboring the bacterial tetR gene, which are resistant to the antibiotic.

Antibiotic substance produced by Streptomyces spp. Antiamebic; antibacterial; antirickettsial.

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Warning
• Hazard statements: H315-H319-H335-H361fd-H410
• Precautionary statements: P202-P261-P273-P302+P352-P305+P351+P338-P308+P313
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-20/21/22
• Safety Statements: 26-36
• WGK Germany: 2
• RTECS: QI9100000
• F: 8-10-23
• TSCA: Yes
• HS Code: 29413000
• Toxicity: LD50 orally in rats: 6443 mg/kg (Goldenthal)