Trimethylsilyl cyanide , 96% , 7677-24-9
Synonym(s):
Cyanotrimethylsilane;TMSCN
CAS NO.：7677-24-9
Empirical Formula: C4H9NSi
Molecular Weight: 99.21
MDL number: MFCD00001765
EINECS: 231-657-3
| Pack Size | Price | Stock | Quantity |
| 5ML | RMB67.20 | In Stock |
|
| 25ML | RMB155.20 | In Stock |
|
| 100ML | RMB416.00 | In Stock |
|
| 500ML | RMB1814.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 8-11 °C(lit.) |
| Boiling point: | 114-117 °C(lit.) |
| Density | 0.793 g/mL at 20 °C(lit.) |
| refractive index | n |
| Flash point: | 34 °F |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Miscible with organic solvents. |
| form | liquid |
| Specific Gravity | 0.744 |
| color | Yellow |
| Water Solubility | reacts |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| BRN | 1737612 |
| Exposure limits | NIOSH: IDLH 25 mg/m3 |
| Stability: | Moisture Sensitive |
| InChIKey | LEIMLDGFXIOXMT-UHFFFAOYSA-N |
| CAS DataBase Reference | 7677-24-9(CAS DataBase Reference) |
| EPA Substance Registry System | Silanecarbonitrile, trimethyl- (7677-24-9) |
Description and Uses
Cyanotrimethylsilane is a highly versatile reagent that reacts with a multitude of functional groups to yield an array of products and/or highly valuable synthetic intermediates.
Aldehydes and ketones are readily transformed into the corresponding cyanohydrin trimethylsilyl ethers when treated with cyanotrimethylsilane in the presence of Lewis acids (eq 1), triethylamine,or solid bases such as CaF2 or hydroxyapatite. The products can be readily hydrolyzed to the corresponding cyanohydrins. The cyanosilylation of aromatic aldehydes can be achieved with high enantioselectivity in the presence of catalytic amounts of a modified Sharpless catalyst consisting of titanium tetraisopropoxide and L-(+)-diisopropyl tartrate (eq 2).Catalysis with chiral titanium reagents yields aliphatic and aromatic cyanohydrins in high chemical and optical yields (eq 3). Cyanohydrins can be subsequently transformed into a variety of useful synthetic intermediates (eq 4).
Safety
| Symbol(GHS) |    GHS02,GHS06,GHS09 |
| Signal word | Danger |
| Hazard statements | H225-H300+H310+H330-H410 |
| Precautionary statements | P210-P233-P273-P280-P303+P361+P353-P304+P340+P310 |
| Hazard Codes | F,T+,T,N |
| Risk Statements | 11-26/27/28-29-50/53 |
| Safety Statements | 16-36/37/39-45-61-28A-26 |
| RIDADR | UN 3384 6.1/PG 1 |
| WGK Germany | 3 |
| F | 10-21 |
| Hazard Note | Highly Flammable/Toxic |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29310095 |
