Tris(2-carboxyethyl)phosphine hydrochloride , 98% , 51805-45-9
Synonym(s):
tris(2-Carboxyethyl)phosphine, HCl;TCEP;TCEP, Hydrochloride - CAS 51805-45-9 - Calbiochem;TCEP, Hydrochloride, Reagent Grade - CAS 51805-45-9 - Calbiochem;TCEP.HCL
CAS NO.：51805-45-9
Empirical Formula: C9H16ClO6P
Molecular Weight: 286.65
MDL number: MFCD00145469
EINECS: 629-759-1
| Pack Size | Price | Stock | Quantity |
| 1G | RMB29.60 | In Stock |
|
| 5G | RMB104.00 | In Stock |
|
| 25G | RMB455.20 | In Stock |
|
| 100g | RMB1732.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 177 °C |
| Density | 1.041 g/mL at 25 °C |
| refractive index | n |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| pka | 7.66(at 25℃) |
| color | white |
| PH | 7.0(aqueous solution; pH was adjusted with ammonium hydroxide) |
| Water Solubility | Soluble in water and methanol. |
| Sensitive | Moisture Sensitive |
| λmax | λ: 260 nm Amax: 0.05 λ: 280 nm Amax: 0.03 |
| Merck | 14,9085 |
| BRN | 3724376 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month. |
| InChI | 1S/C9H15O6P.ClH/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15;/h1-6H2,(H,10,11)(H,12,13)(H,14,15);1H |
| InChIKey | PBVAJRFEEOIAGW-UHFFFAOYSA-N |
| SMILES | Cl[H].OC(=O)CCP(CCC(O)=O)CCC(O)=O |
| CAS DataBase Reference | 51805-45-9(CAS DataBase Reference) |
Description and Uses
TCEP HCl (51805-45-9) is a reagent for selective reduction of disulfides in aqueous solutions1-3with distinct advantages over DTT which are application specific3. For example, spin labels are more stable with TCEP than DTT, Ni2+(leached from affinity columns) causes rapid oxidation of DTT with no effect on TCEP and for long term storage of proteins TCEP is more stable than DTT with no metal chelator (EGTA) present but DTT is more stable in the presence of metal chelators.3
Reducing agent, specific for disulfidesTris(2-carboxyethyl)phosphine hydrochloride is widely used as a reducing agent to reduce disulfide bonds in proteins and trans-4,5-dihydroxy-1,2-dithiane. It is involved in the reduction of sulfoxides, sulfonyl chlorides, N-oxides, and azides. It plays an important role in the tissue homogenization process for RNA isolation. It acts as a chelating agent and forms complexes with various heavy metal ions such as Zn(II), Cd(II), Pb(II), and Ni(II). Furthermore, it is useful in the labeling of cysteine residues with maleimides.
Safety
| Symbol(GHS) |  GHS05 |
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | C,Xi |
| Risk Statements | 36/38-36/37/38-34 |
| Safety Statements | 26-37/39-36/37/39-27-45 |
| RIDADR | UN 3261 8/PG 2 |
| WGK Germany | 2 |
| F | 10 |
| TSCA | No |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29319090 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Eye Dam. 1 Skin Corr. 1B |
| Limited Quantities | 1 Kg (2.2 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) |
