2,2,2-Trichloroethanol , 98% , 115-20-8

Synonym(s):
ß,ß,ß-Trichloroethyl alcohol;2,2,2-Trichloroethanol;Trichloroethyl alcohol

CAS NO.：115-20-8

Empirical Formula: C2H3Cl3O

Molecular Weight: 149.4

MDL number: MFCD00004677

EINECS: 204-071-0

PRODUCT Properties

• Melting point: 17.8 °C (lit.)
• Boiling point: 152-154 °C (lit.)
• Density: 1.56 g/mL at 20 °C (lit.)
• vapor density: 5.16 (vs air)
• vapor pressure: 1 mm Hg ( 20 °C)
• refractive index: n20/D 1.49(lit.)
• Flash point: >230 °F
• storage temp.: Store below +30°C.
• solubility: 83g/l
• form: Liquid
• pka: 12.24(at 25℃)
• color: Clear colorless to light yellow
• Specific Gravity: 1.560 (20/4℃)
• Odor: ethereal odor
• PH: 5-6 (H2O, 20℃)(saturated solution)
• Water Solubility: Slightly soluble in water.
• Sensitive: Hygroscopic
• Merck: 14,9638
• BRN: 1697495
• CAS DataBase Reference: 115-20-8(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2,2,2-trichloro-(115-20-8)
• EPA Substance Registry System: 2,2,2-Trichloroethanol (115-20-8)

Description and Uses

The 2,2,2-Trichloroethyl (TCE) moiety of 2,2,2-trichloroethanol is mainly used as a protecting group for acids, acetals and also phosphoryl groups of nucleotides. It can be easily cleaved by zinc reduction.
Some of its other application include:

• Conversion of per-O-acetylated sugars to per-O-acetylated trichloroethyl derivatives.
• Preparation of TCE ester of chlorosulfuric acid.
• Preparation of 2,2,2-trichloroethyl acetimidate hydrochloride.

Safety

• Symbol(GHS): GHS05,GHS07
• Signal word: Danger
• Hazard statements: H302-H318-H336
• Precautionary statements: P261-P280-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-41-67
• Safety Statements: 26-39
• RIDADR: 1760
• WGK Germany: 1
• RTECS: KM3850000
• F: 3-21
• Autoignition Temperature: 151°C
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• HS Code: 29055910
• Toxicity: LDLo orl-rat: 500 mg/kg CRAAA7 17,258,38