GNE-9605 , 10mMinDMSO , 1536200-31-3
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 587.9±60.0 °C(Predicted) |
| Density | 1.67±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | ≥22.5 mg/mL in DMSO |
| form | solid |
| pka | 5.04±0.60(Predicted) |
| color | White to off-white |
| InChIKey | PUXPEQJKNAWNQA-PZILLZCRNA-N |
| SMILES | C1(NC2=C(Cl)N([C@@H]3CCN(C4COC4)C[C@H]3F)N=C2)=NC=C(C(F)(F)F)C(NC)=N1 |&1:6,15,r| |
Description and Uses
GNE-9065 is an orally bioavailable and potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 18.7 nM). It is selective for LRRK2 over 178 kinases, inhibiting only TAK1-TAB1 >50% at a concentration of 0.1 μM. GNE-9065 (10 and 50 mg/kg) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S mutation found in families with autosomal Parkinson’s disease.
GNE-9605 is a potent, orally active, selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC50 value of 18.7 nM. GNE-9605 inhibits LRRK2 Ser1292 autophosphorylation. GNE-9605 can be used in research of Parkinson's disease (PD) [1].
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H302-H400-H410 |
| Precautionary statements | P264-P270-P273-P301+P312-P330-P391-P501 |
