Losartan , 10mMinDMSO , 114798-26-4

Synonym(s):
1-[1-[[2′-(2H-Tetrazol-5-yl)biphenyl-4-yl]methyl]-2-butyl-4-chloro-1H-imidazol-5-yl]methanol;2-Butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-1H-imidazole-5-methanol;2-Butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol;DUP 89

CAS NO.：114798-26-4

Empirical Formula: C22H23ClN6O

Molecular Weight: 422.91

MDL number: MFCD00865831

EINECS: 601-329-8

PRODUCT Properties

• Melting point: 183-184 C
• Boiling point: 682.0±65.0 °C(Predicted)
• Density: 1.35±0.1 g/cm3(Predicted)
• vapor pressure: 0.002Pa at 20℃
• storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 5-6(at 25℃)
• color: White to Off-White
• Water Solubility: 4.8mg/L at 20℃
• InChI: 1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
• InChIKey: PSIFNNKUMBGKDQ-UHFFFAOYSA-N
• SMILES: OCC1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=C(C4=NNN=N4)C=CC=C3)C=C2
• LogP: 1.1 at 20℃
• CAS DataBase Reference: 114798-26-4(CAS DataBase Reference)
• EPA Substance Registry System: 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (114798-26-4)

Description and Uses

Losartan is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H317-H360FD-H362
• Precautionary statements: P202-P260-P263-P280-P302+P352-P308+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: WGK 3
• Storage Class: 6.1C - Combustible acute toxic Cat.3; toxic compounds or compounds which causing chronic effects
• Hazard Classifications: Lact.; Repr. 1B; Skin Sens. 1
• Hazardous Substances Data: 114798-26-4(Hazardous Substances Data)