Tolfenamic Acid , ≥98% , 13710-19-5

Synonym(s):
2 (3-Chloro-2-methylanilino)benzoic acid;2-([3-Chloro-2-methylphenyl]amino)benzoic acid;Tolfenamic acid

CAS NO.：13710-19-5

Empirical Formula: C14H12ClNO2

Molecular Weight: 261.7

MDL number: MFCD00133865

EINECS: 237-264-3

PRODUCT Properties

• Melting point: 210-214°C
• Boiling point: 405.4±40.0 °C(Predicted)
• Density: 1.2037 (rough estimate)
• refractive index: 1.5270 (estimate)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, soluble in dimethylformamide, sparingly soluble in ethanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.
• form: Solid
• pka: 3.66±0.36(Predicted)
• color: White to Off-White
• Water Solubility: Soluble in water (slightly), acetone (~10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (~10 mg/ml) and ethanol (50 mg/ml).
• Merck: 14,9513
• InChI: InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)
• InChIKey: YEZNLOUZAIOMLT-UHFFFAOYSA-N
• SMILES: C(O)(=O)C1=CC=CC=C1NC1=CC=CC(Cl)=C1C
• CAS DataBase Reference: 13710-19-5(CAS DataBase Reference)
• EPA Substance Registry System: Benzoic acid, 2-[(3-chloro-2-methylphenyl)amino]- (13710-19-5)

Description and Uses

Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 μM.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P264-P270-P301+P310-P405-P501
• Hazard Codes: Xn
• Risk Statements: 22
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: CB2687500
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29224919
• Limited Quantities: 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
• Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)