3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride , 97% , 762240-92-6

CAS NO.：762240-92-6

Empirical Formula: C6H8ClF3N4

Molecular Weight: 228.6

MDL number: MFCD09817638

EINECS: 616-309-4

PRODUCT Properties

• Melting point: 236-246°C
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• color: White to Off-White
• InChI: InChI=1S/C6H7F3N4.ClH/c7-6(8,9)5-12-11-4-3-10-1-2-13(4)5;/h10H,1-3H2;1H
• InChIKey: AQCSCRYRCRORET-UHFFFAOYSA-N
• SMILES: C12=NN=C(C(F)(F)F)N1CCNC2.[H]Cl
• CAS DataBase Reference: 762240-92-6(CAS DataBase Reference)

Description and Uses

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride is a pharmaceutical intermediate compound used in the preparation of Sitagliptin phosphate. Sitagliptin is an oral hypoglycaemic agent, a dipeptidyl peptidase-4 inhibitor, which is used in the treatment of type 2 diabetes.

Sitagliptin intermediate.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 45
• RIDADR: UN2811
• HS Code: 2933599577