UNC1999 , ≥98% , 1431612-23-5

Synonym(s):
1-Isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide

CAS NO.：1431612-23-5

Empirical Formula: C33H43N7O2

Molecular Weight: 569.74

MDL number: MFCD26960958

PRODUCT Properties

• Boiling point: 804.7±65.0 °C(Predicted)
• Density: 1.23±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: soluble15mg/mL, clear
• pka: 11.84±0.10(Predicted)
• form: powder
• color: white to beige
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
• InChIKey: DPJNKUOXBZSZAI-UHFFFAOYSA-N
• SMILES: CC(C)N1CCN(C2=NC=C(C3=CC4=C(C=NN4C(C)C)C(C(NCC5=C(CCC)C=C(C)NC5=O)=O)=C3)C=C2)CC1
• CAS DataBase Reference: 1431612-23-5

Description and Uses

UNC1999 (1431612-23-5) is an orally bioavailable, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50‘s = 45 nM and 2 nM respectively).1Inhibition of EZH2 with UNC1999 enhanced the efficacy of gefitinib (Cat.# 10-1148) in suppressing the proliferation of colon cancer cells

UNC1999 acts as an inhibitor for lysine methyltransferases EZH2 and EZH1 which have been implicated in the expression of various cancers.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P280-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22
• WGK Germany: 3
• Storage Class: 11 - Combustible Solids