Uric acid sodium salt , 0 , 1198-77-2

Synonym(s):
2,6,8-Trihydroxypurine;Sodium acid urate

CAS NO.：1198-77-2

Empirical Formula: C5H3N4NaO3

Molecular Weight: 190.09

MDL number: MFCD00067310

EINECS: 214-838-1

PRODUCT Properties

• storage temp.: Store at -20°C
• solubility: 1 M NaOH: 25 mg/ml
• form: Solution may appear as a slightly hazy suspension.
• color: Liquid
• biological source: microbial; synthetic
• Stability: Stable.
• InChI: 1S/C5H4N4O3.Na.H/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;;/h(H4,6,7,8,9,10,11,12)
• InChIKey: IHMJZGFANDMEJM-UHFFFAOYSA-N
• SMILES: [Na].O=C1NC(=O)C2=C(N1)NC(=O)N2
• CAS DataBase Reference: 1198-77-2
• EPA Substance Registry System: 1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-, monosodium salt (1198-77-2)

Description and Uses

Uric acid is a ubiquitous end product of purine metabolism in humans that is mainly excreted in urine, whereas in other mammals it is further metabolized to allantoin by uricase. The final two steps in its production are catalyzed by xanthine oxidase, which generates superoxide. Uric acid acts as a potent peroxynitrite scavenger and antioxidant. However, high levels of serum uric acid (>120 μg/ml), termed hyperuricemia, are associated with gout, kidney stones, metabolic syndrome, hypertension, renal disease, and cardiovascular disease. Uric acid in the form of monosodium urate crystals has been proposed to trigger interleukin-1β-mediated inflammation by activating the NOD-like receptor protein 3 inflammasome.

Uric acid sodium salt has been used in isotonic solution of NaCl dose titration study. It has been used as a suspension in NaCl for intra-articular administration to experimental animals to induce synovitis.

Safety

• PPE: Eyeshields, Gloves, type N95 (US)
• WGK Germany: 3
• RTECS: YU7062000
• TSCA: TSCA listed
• Storage Class: 11 - Combustible Solids