Venlafaxine hydrochloride , ≥98%(HPLC) , 99300-78-4
Synonym(s):
(+/-)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride;Effexor;Venlafaxine hydrochloride
CAS NO.：99300-78-4
Empirical Formula: C17H28ClNO2
Molecular Weight: 313.86
MDL number: MFCD03658865
EINECS: 619-421-1
| Pack Size | Price | Stock | Quantity |
| 1G | RMB32.00 | In Stock |
|
| 5G | RMB74.40 | In Stock |
|
| 25G | RMB227.20 | In Stock |
|
| 100G | RMB779.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 207-209°C |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | H2O: >10mg/mL |
| form | powder |
| color | white |
| Water Solubility | water: 100mM DMSO: 50mM |
| Merck | 14,9946 |
| BCS Class | 1 |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H |
| InChIKey | QYRYFNHXARDNFZ-UHFFFAOYSA-N |
| SMILES | OC1(CCCCC1)C(C1=CC=C(OC)C=C1)CN(C)C.[H]Cl |
| CAS DataBase Reference | 99300-78-4(CAS DataBase Reference) |
| EPA Substance Registry System | Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, hydrochloride (1:1 (99300-78-4) |
Description and Uses
Venlafaxine hydrochloride, a novel phenethylamine derivative, was introduced in the U.S.A. as an antidepressant. Venlafaxine is reported to be the first in the class of the second-generation of antidepressants with dual serotonidnorepinephrine reuptake inhibitory activity. Venlafaxine lacks any affinity for muscarinic, cholinergic, histaminergic and noradrenergic receptors and therefore, has an unusually favorable side effect profile compared with classical tricyclic antidepressants and shows less cardiotoxicity. In addition, venlafaxine has a rapid onset of action that makes it unique among the antidepressant agents. Other indications for venlafaxine include the treatment of obsessive and panic disorders, and obesity. Both enantiomers of venlafaxine were reported to have similar biological activity.
Venlafaxine hydrochloride is an inhibitor of reuptake of both serotonin (IC50 = 0.21 μM) and norepinephrine (IC50 = 0.64 μM). It is effective in vitro and in vivo and against human as well as rat receptors. As an antidepressant, it is properly placed in the serotonin-norepinephrine reuptake inhibitor class.[Cayman Chemical]
Safety
| Symbol(GHS) |  GHS09 |
| Signal word | Danger |
| Hazard statements | H411 |
| Precautionary statements | P273-P391-P501 |
| Hazard Codes | Xi,T,F |
| Risk Statements | 36/37/38-36-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-37/39-45-36/37-16-7 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | GV8872760 |
| HS Code | 29225090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Chronic 2 |
