WY-14643 (Pirinixic Acid) , ≥98% , 50892-23-4

Synonym(s):
4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid;Pirinixic acid

CAS NO.：50892-23-4

Empirical Formula: C14H14ClN3O2S

Molecular Weight: 323.8

MDL number: MFCD00191335

PRODUCT Properties

• Melting point: 155°C
• Boiling point: 514.4±50.0 °C(Predicted)
• Density: 1.2984 (rough estimate)
• refractive index: 1.5630 (estimate)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: Soluble in DMSO (up to 40 mg/ml).
• form: White crystalline solid
• pka: 2.99±0.10(Predicted)
• color: Off-white
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
• InChI: 1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)
• InChIKey: SZRPDCCEHVWOJX-UHFFFAOYSA-N
• SMILES: CC1=C(C)C=CC=C1NC2=NC(SCC(O)=O)=NC(Cl)=C2

Description and Uses

WY-14643 (50892-23-4) is a selective PPARα agonist (EC50=0.63, 32 and >100 μM for PPARα,γ and δ, respectively).1? Displays anti-inflammatory activity2 and reduces LPS-induced inflammation in alveolar epithelial cells3. Induces “browning” of white adipocytes in combined treatment with retinoic acid.4? Stimulates ADAM10-mediated proteolysis of? amyloid precursor protein in a mouse model.5 Down regulates NFkB transcriptional activity. Review.6

A highly potent PPARα agonist

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H315-H319-H335-H350
• Precautionary statements: P201-P301+P312+P330-P302+P352-P305+P351+P338-P308+P313
• target organs: Respiratory system
• PPE: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
• Hazard Codes: T
• Risk Statements: 45-22-36/37/38
• Safety Statements: 53-26-36/37/39-45
• WGK Germany: 3
• RTECS: AG2915000
• HS Code: 2933.59.9500
• Storage Class: 6.1C - Combustible acute toxic Cat.3; toxic compounds or compounds which causing chronic effects
• Hazard Classifications: Acute Tox. 4 Oral; Carc. 1B; Eye Irrit. 2; Skin Irrit. 2; STOT SE 3
• Hazardous Substances Data: 50892-23-4(Hazardous Substances Data)