(±)-Baclofen , ≥98.0% , 1134-47-0

Synonym(s):
(±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid;(±)-Baclofen;Lioresal

CAS NO.：1134-47-0

Empirical Formula: C10H12ClNO2

Molecular Weight: 213.66

MDL number: MFCD00055143

EINECS: 214-486-9

PRODUCT Properties

• Melting point: 208-210°C
• Boiling point: 364.3±32.0 °C(Predicted)
• Density: 1.2069 (rough estimate)
• refractive index: 1.5500 (estimate)
• storage temp.: 2-8°C
• solubility: 1 M HCl: 50 mg/mL
• form: solid
• pka: pKa 3.87±0.1(H2O) (Uncertain)
• color: white to very faintly yellow
• Water Solubility: Soluble in dilute NaOH or dilute HCl. Soluble in water at approximately 4mg/ml at pH 7.6
• Merck: 14,937
• Stability: Hygroscopic
• InChI: InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
• InChIKey: KPYSYYIEGFHWSV-UHFFFAOYSA-N
• SMILES: C1(C=CC(Cl)=CC=1)C(CN)CC(=O)O
• CAS DataBase Reference: 1134-47-0(CAS DataBase Reference)
• NIST Chemistry Reference: Baclofen(1134-47-0)
• EPA Substance Registry System: .beta.-(Aminomethyl)-4-chlorobenzenepropanoic acid (1134-47-0)

Description and Uses

Specific GABA-B receptor agonist. Muscle relaxant (skeletal)

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P301+P330+P331+P310
• Hazard Codes: T,Xn
• Risk Statements: 61-25-36/37/38-42/43-20/21/22
• Safety Statements: 53-22-36/37/39-45-52-36-26
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: MW5084200
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 2922492050
• Toxicity: LD50 in male mice, rats (mg/kg): 45, 78 i.v.; 103, 115 s.c.; 200, 145 orally (Tadokoro)
• Limited Quantities: 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
• Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)