Zebularine , ≥98%(HPLC) , 3690-10-6

Synonym(s):
1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside;Zebularine - CAS 3690-10-6 - Calbiochem

CAS NO.：3690-10-6

Empirical Formula: C9H12N2O5

Molecular Weight: 228.2

MDL number: MFCD04973699

EINECS: 2017-001-1

PRODUCT Properties

• Melting point: 160-162?C
• Boiling point: 499.0±55.0 °C(Predicted)
• Density: 1.73±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: 16 mg/mL, soluble
• form: solid
• pka: 13.48±0.70(Predicted)
• color: White
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
• InChI: InChI=1/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2/t5-,6-,7-,8-/s3
• InChIKey: RPQZTTQVRYEKCR-WCTZXXKLSA-N
• SMILES: N1(C=CC=NC1=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |&1:7,9,12,14,r|

Description and Uses

Zebularine (3690-10-6) is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Zebularine inhibits cytidine deaminase (Ki ~ 2 μM and; induces differentiation of mesenchymal stem cells into cardiomyocytes.

It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H320-H335
• Precautionary statements: P264-P270-P301+P312-P330
• WGK Germany: 3
• RTECS: UW7539720
• HS Code: 2934999090