Tos-peg4-t-butylester , 95% , 217817-01-1
| Pack Size | Price | Stock | Quantity |
| 100mg | RMB132.00 | In Stock |
|
| 250mg | RMB263.20 | In Stock |
|
| 1g | RMB627.20 | In Stock |
|
| 5g | RMB2202.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 528.5±45.0 °C(Predicted) |
| Density | 1.154±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | Liquid |
| color | Colorless to light yellow |
Description and Uses
Tos-PEG4-t-butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 |
