![5-Chloropyrazolo[1,5-a]pyrimidine](https://img.chemicalbook.com/CAS/GIF/29274-24-6.gif)
5-Chloropyrazolo[1,5-a]pyrimidine , 97% , 29274-24-6
| Pack Size | Price | Stock | Quantity |
| 250mg | RMB32.00 | In Stock |
|
| 1g | RMB44.00 | In Stock |
|
| 5g | RMB141.60 | In Stock |
|
| 10g | RMB270.40 | In Stock |
|
| 25g | RMB549.60 | In Stock |
|
| 100g | RMB1647.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Density | 1.51±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -0.49±0.30(Predicted) |
| Appearance | Light brown to yellow Solid |
| InChI | InChI=1S/C6H4ClN3/c7-5-2-4-10-6(9-5)1-3-8-10/h1-4H |
| InChIKey | WEPRLWNMBTYGGD-UHFFFAOYSA-N |
| SMILES | C12=CC=NN1C=CC(Cl)=N2 |
Description and Uses
5-Chloropyrazolo[1,5-a]pyrimidine is formed by replacing the hydrogen atom at position 5 of the pyrazolo[1,5-a]pyrimidine compound structure with a chlorine atom. It can serve as a pharmaceutical intermediate for synthesising other bioactive compounds. Pyrazolo[1,5-a]pyrimidine derivatives function as ATP-competitive and allosteric inhibitors of protein kinases, with those targeting the epidermal growth factor receptor (EGFR) demonstrating potential in the treatment of non-small cell lung cancer (NSCLC).
5-Chloropyrazolo[1,5-a]pyrimidine was used in the preparation of β-substituted biarylphenylalanine amides as selective amino amide dipeptidyl peptidase IV inhibitors for treatment of type 2 diabetes.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| RIDADR | UN2811 |
| HazardClass | IRRITANT |
| HS Code | 2933599590 |
