2,4-Dichloro-3-nitroquinoline , 95% , 132521-66-5

CAS NO.：132521-66-5

Empirical Formula: C9H4Cl2N2O2

Molecular Weight: 243.05

MDL number: MFCD05666285

PRODUCT Properties

• Melting point: 102 °C(Solv: methanol (67-56-1); ethyl acetate (141-78-6))
• Boiling point: 359.7±37.0 °C(Predicted)
• Density: 1.593±0.06 g/cm3(Predicted)
• storage temp.: -20°C Freezer
• solubility: Chloroform (Slightly), Methanol (Slightly)
• form: Solid
• pka: -4.98±0.50(Predicted)
• color: White to Off-White
• InChI: InChI=1S/C9H4Cl2N2O2/c10-7-5-3-1-2-4-6(5)12-9(11)8(7)13(14)15/h1-4H
• InChIKey: RSFJVCHKGRUCIC-UHFFFAOYSA-N
• SMILES: N1C2C(=CC=CC=2)C(Cl)=C([N+]([O-])=O)C=1Cl

Description and Uses

2,4-Dichloro-3-nitroquinoline is a chemotherapeutic drug that belongs to the class of epidermal growth factor receptor (EGFR) inhibitors. This agent has anticancer activity against cells in the G1 phase of the cell cycle and may also have some antiproliferative effects on tumor cells. 2,4-Dichloro-3-nitroquinoline binds to EGFR and inhibits the binding of epidermal growth factor (EGF) to its receptor. This binding causes the activation of downstream signaling pathways that regulate cell proliferation.

2,4-Dichloro-3-nitroquinoline has antitumor activity.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• HS Code: 2933499090