BD0640653
2-(3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)aceticacid , 97% , 72702-95-5
CAS NO.：72702-95-5
Empirical Formula: C17H12BrFN2O3
Molecular Weight: 391.19
MDL number: MFCD00204117
| Pack Size | Price | Stock | Quantity |
| 25mg | RMB345.60 | In Stock |
|
| 50mg | RMB586.40 | In Stock |
|
| 100mg | RMB996.80 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 184-186℃ (DEC.) |
| Density | 1.60 |
| storage temp. | Store at RT |
| solubility | DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL |
| form | A crystalline solid |
| color | White to off-white |
| InChI | InChI=1S/C17H12BrFN2O3/c18-11-6-5-10(14(19)7-11)9-21-17(24)13-4-2-1-3-12(13)15(20-21)8-16(22)23/h1-7H,8-9H2,(H,22,23) |
| InChIKey | LKBFFDOJUKLQNY-UHFFFAOYSA-N |
| SMILES | C12C=CC=CC=1C(=O)N(CC1=CC=C(Br)C=C1F)N=C2CC(=O)O |
Description and Uses
Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes.
Inhibitor (aldose reductase).
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
