tert-Butyl3-(2-(2-(tosyloxy)ethoxy)ethoxy)propanoate , 97% , 850090-13-0

CAS NO.：850090-13-0

Empirical Formula: C18H28O7S

Molecular Weight: 388.48

MDL number: MFCD27635184

PRODUCT Properties

• Boiling point: 495.2±35.0 °C(Predicted)
• Density: 1.159±0.06 g/cm3(Predicted)
• storage temp.: Storage temp. 2-8°C
• form: Liquid
• color: Colorless to light yellow

Description and Uses

Tos-PEG3-t-butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Tos-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338