(E)-3-(3,4,5-Trimethoxyphenyl)acrylic acid , 98% , 20329-98-0

CAS NO.：20329-98-0

Empirical Formula: C12H14O5

Molecular Weight: 238.24

MDL number: MFCD00004388

EINECS: 201-999-8

PRODUCT Properties

• Melting point: 125-127 °C(lit.)
• Boiling point: 396.4±37.0 °C(Predicted)
• Density: 1.209±0.06 g/cm3(Predicted)
• storage temp.: Sealed in dry,Room Temperature
• pka: 4.48±0.10(Predicted)
• form: powder to crystal
• color: White to Light yellow
• InChI: InChI=1S/C12H14O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h4-7H,1-3H3,(H,13,14)/b5-4+
• InChIKey: YTFVRYKNXDADBI-SNAWJCMRSA-N
• SMILES: C(O)(=O)/C=C/C1=CC(OC)=C(OC)C(OC)=C1

Description and Uses

(E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy[1][2][3].

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Safety Statements: 24/25
• WGK Germany: 2
• RTECS: GE0722000
• HS Code: 2918.99.4700