SR0987 , 98% , 303126-97-8
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB302.40 | In Stock |
|
| 10mg | RMB594.40 | In Stock |
|
| 25mg | RMB892.00 | In Stock |
|
| 50mg | RMB1338.40 | In Stock |
|
| 100mg | RMB2008.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 378.8±42.0 °C(Predicted) |
| Density | 1.525±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml) |
| pka | 9.22±0.15(Predicted) |
| form | solid |
| color | White |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
Description and Uses
SR 0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA and ionomycin , increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged. Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987.
SR 0987 is a RORγt agonist.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
