4,6-Dioxoheptanoicacid , 97% , 51568-18-4
Synonym(s):
Succinylacetone;Succinylacetone-3,4,5,6,7-13C5
| Pack Size | Price | Stock | Quantity |
| 100mg | RMB516.00 | In Stock |
|
| 250mg | RMB900.00 | In Stock |
|
| 1g | RMB1916.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 66-67 °C(lit.) |
| Boiling point: | 318.7±17.0 °C(Predicted) |
| Density | 1.189±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 4.54±0.17(Predicted) |
| form | powder |
| color | White to Off-White |
| Appearance | white solid |
| InChI | InChI=1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11) |
| InChIKey | WYEPBHZLDUPIOD-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CCC(=O)CC(=O)C |
| CAS DataBase Reference | 51568-18-4 |
Description and Uses
Succinylacetone (4,6-dioxoheptanoic acid), is a result of tyrosine metabolism disorder. The synthesis of this medium-chain keto acid in the body is due to the reduced activity of the enzyme fumarylacetoacetate hydrolase. Succinylacetone is an acidogen, its high concentrations can lead to metabolic acidosis, which leads to damage to the liver, kidneys, heart, and nervous system. Succinylacetone appears to be an oncometabolite because patients with high levels of this compound often develop hepatocellular carcinoma.
Succinylacetone is widely used in research as an inhibitor of the enzyme 5-aminolevulinic acid dehydratase (ALAD), which plays a key role in heme biosynthesis.
The product is used primarily as a control for MS/MS.
4,6-Dioxoheptanoic acid has been used:
- as component of dendritic cell conditioning medium and in the inhibition of ALA dehydratase (ALAD) in dendritic cells(50)
- as an inhibitor of heme biosynthesis in human mononuclear cells(51) and HeLa cells(52)
- as a standard for the quantification of succinylacetone from Plasmodium falciparum cultures(53)
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
