Sugammadexsodium , 97% , 343306-79-6

CAS NO.：343306-79-6

Empirical Formula: C72H104Na8O48S8

Molecular Weight: 2177.97

MDL number: MFCD09954145

PRODUCT Properties

• storage temp.: Inert atmosphere,Room Temperature
• solubility: DMF: 2.5 mg/ml; DMSO: 2.5 mg/ml; DMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml
• form: A crystalline solid
• color: White to off-white
• Water Solubility: H2O: 2mg/mL, clear
• InChIKey: NIOBYNJFPSIMJF-OBHNVPISNA-N

Description and Uses

To facilitate tracheal intubation, mechanical ventilation, and surgical access, NMB agents are frequently used as non-anesthetic adjuncts in surgical procedures. Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizing neuromuscular blocker, without the cardiovascular adverse effects experienced with reversal agents that directly interact with the cholinergic system. The γ-cyclodextrin has been designed to enhance binding of the guest by incorporating acidic side chains to promote an electrostatic interaction with the positive nitrogen of the blocker. Starting with γ-cyclodextrin, these side chains are readily installed by first halogenating with iodine or bromine to provide a handle for nucleophilic displacement with either 3-mercaptopropionic acid in the presence of sodium hydride or with 3-mercaptopropionic acid methyl ester and cesium carbonate. The latter requires hydrolysis with sodium hydroxide to generate sugammadex sodium.

Sugammadex Sodium is the first in a class of drugs called selective relaxant binding agents that offers improved termination of the paralytic effects of neuromuscular blocking agents and may have many potential peri-operative benefits.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H302-H334
• Precautionary statements: P264-P270-P301+P312-P330-P501-P261-P285-P304+P341-P342+P311-P501