Hydroxyflutamide , 98% , 52806-53-8

Synonym(s):
2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide;2-Hydroxyflutamide;a,a,a-Trifluoro-2-methyl-4′-nitro-m-lactotoluidide;Hydroxyniphtholide;Sch 16423

CAS NO.：52806-53-8

Empirical Formula: C11H11F3N2O4

Molecular Weight: 292.21

MDL number: MFCD00563126

PRODUCT Properties

• Melting point: 125-130°C
• Boiling point: 443.8±45.0 °C(Predicted)
• Density: 1.472
• storage temp.: room temp
• solubility: DMSO: >10mg/mL
• form: powder
• pka: 12.87±0.70(Predicted)
• color: white to tan

Description and Uses

2-hydroxy Flutamide is the major metabolite formed during the metabolism of the non-steroidal antiandrogen flutamide by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4. Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC₅₀ = ~300-900), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR. Compared to flutamide, 2-hydroxy flutamide is a more potent antiandrogen in vivo, demonstrating a higher binding affinity for the AR (0.1% binding affinity relative to dihydrotestosterone) and, thus, is the predominant contributor to the therapeutic effects of flutamide in the treatment of prostate cancer.

HYDROXYFLUTAMIDE is used non-steroidal antagonist Flutamide. Shown to be an antianhydrogen.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• RTECS: TX1466250
• HS Code: 2924297099