Sodium2-((2,6-dichloro-3-methylphenyl)amino)benzoate , 99% , 6385-02-0

Synonym(s):
2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt;Meclofenamic acid sodium salt

CAS NO.：6385-02-0

Empirical Formula: C14H10Cl2NO2.Na

Molecular Weight: 318.13

MDL number: MFCD00941475

EINECS: 228-983-3

PRODUCT Properties

• Melting point: 287-291 °C
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: White solid.
• color: White to Off-White
• biological source: synthetic (organic)
• Water Solubility: Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
• Merck: 14,5779
• Stability: Hygroscopic
• Major Application: pharmaceutical
• InChI: 1S/C14H11Cl2NO2.Na.H/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19)
• InChIKey: CHGIZYUDGOIAFY-UHFFFAOYSA-N
• SMILES: [Na].Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl

Description and Uses

Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC₅₀ values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 μM, respectively for instantaneous inhibition. However, the IC₅₀ is much lower if pre-incubated with the enzyme.

antiinflammatory, antipyretic

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P280-P305+P351+P338
• WGK Germany: 3
• RTECS: CB2975500
• HS Code: 2922498050
• Storage Class: 11 - Combustible Solids