Sodium(S)-2-hydroxypentanedioate , 95% , 63512-50-5

Synonym(s):
(S)-2-Hydroxypentanedioic acid disodium salt;Disodium (S)-2-hydroxyglutarate

CAS NO.：63512-50-5

Empirical Formula: C5H6O5Na2

Molecular Weight:

MDL number: MFCD00021700

PRODUCT Properties

• Melting point: >300°C
• storage temp.: 2-8°C
• solubility: Methanol (Very Slightly), Water (Slightly)
• form: Solid
• color: White to Off-White
• optical activity: [α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH
• BRN: 5318042
• Major Application: clinical testing
• InChI: 1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1
• InChIKey: DZHFTEDSQFPDPP-QTNFYWBSSA-L
• SMILES: [O-]C(CC[C@@H](C([O-])=O)O)=O.[Na+].[Na+]

Description and Uses

L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels. L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.

L-α-Hydroxyglutaric acid disodium salt is suitable for use in collection buffer for increased recovery of hypoxia-inducible factor-1 α (HIF-1α), a marker of hypoxia in human tumors. It is also suitable for the radiolabeled 5mC-5hmC conversion assay to study the effect of 2-HG on the TET family of methyl hydroxylases.

Safety

• WGK Germany: 3
• Storage Class: 13 - Non Combustible Solids