1-(1H-Benzo[d]imidazol-2-yl)guanidine , 95% , 5418-95-1

CAS NO.：5418-95-1

Empirical Formula: C8H9N5

Molecular Weight: 175.19

MDL number: MFCD00005590

EINECS: 226-527-8

PRODUCT Properties

• Melting point: 242-244 °C (dec.) (lit.)
• Boiling point: 296.48°C (rough estimate)
• Density: 1.2954 (rough estimate)
• refractive index: 1.6900 (estimate)
• storage temp.: Sealed in dry,Room Temperature
• solubility: Soluble in DMSO (up to 50 mg/ml) or in Water (up to 4 mg/ml with warming)
• form: solid
• pka: 13.67±0.30(Predicted)
• color: Beige
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
• CAS DataBase Reference: 5418-95-1(CAS DataBase Reference)
• EPA Substance Registry System: Guanidine, 1H-benzimidazol-2-yl- (5418-95-1)

Description and Uses

2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1?2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3? Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4

N-1H-Benzimidazol-2-ylguanidine is used as a reagent in the synthesis of novel fused pyrimidines and imidazoles as potential analgesics.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H332-H335
• Precautionary statements: P261-P280-P305+P351+P338
• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 2933998090