Clorgilinehydrochloride , 98% , 17780-75-5

Synonym(s):
Clorgyline

CAS NO.：17780-75-5

Empirical Formula: C13H16Cl3NO

Molecular Weight: 308.63

MDL number: MFCD00052012

EINECS: 241-760-5

PRODUCT Properties

• storage temp.: 2-8°C
• solubility: ≥17.65 mg/mL in DMSO; ≥18.2 mg/mL in EtOH; ≥24.8 mg/mL in H2O
• form: A crystalline solid
• color: White to off-white
• InChI: 1S/C13H15Cl2NO.ClH/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15;/h1,5-6,10H,4,7-9H2,2H3;1H
• InChIKey: BBAZDLONIUABKI-UHFFFAOYSA-N
• SMILES: Cl.CN(CCCOc1ccc(Cl)cc1Cl)CC#C

Description and Uses

Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (K_is = 0.054 and 58 μM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin receptors, but it does inhibit the sigma receptor σ₁ on Jurkat human T lymphocyte cells (IC₅₀ = 31 nM). As MAO-A preferentially oxidizes serotonin, selective MAO-A inhibitors have applications in ameliorating depression and anxiety.

Antidepressant;Monoamine oxidase A inhibitor

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301-H312+H332
• Precautionary statements: P261-P264-P280-P301+P310-P302+P352+P312-P304+P340+P312
• PPE: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• Hazard Codes: Xn
• Risk Statements: 20/21/22
• Safety Statements: 36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: UI0675000
• HazardClass: 6.1(b)
• PackingGroup: III
• Storage Class: 6.1C - Combustible acute toxic Cat.3; toxic compounds or compounds which causing chronic effects
• Hazard Classifications: Acute Tox. 3 Oral