SB-225002 , 98% , 182498-32-4

Synonym(s):
N-(2-Hydroxy-4-nitrophenyl)-Nʹ-(2-bromophenyl)urea, CXCR2 Antagonist II;N-(2-Hydroxy-4-nitrophenyl)-N′-(2-bromophenyl)urea;SB 225002 - CAS 182498-32-4 - Calbiochem;SB-225002

CAS NO.：182498-32-4

Empirical Formula: C13H10BrN3O4

Molecular Weight: 352.14

MDL number: MFCD00954637

PRODUCT Properties

• Boiling point: 401.6±45.0 °C(Predicted)
• Density: 1.793±0.06 g/cm3(Predicted)
• storage temp.: room temp
• solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
• form: Yellow solid
• pka: 5.29±0.10(Predicted)
• color: white to beige
• Sensitive: Moisture Sensitive
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• InChI: 1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
• InChIKey: MQBZVUNNWUIPMK-UHFFFAOYSA-N
• SMILES: Brc1c(cccc1)NC(=O)Nc2c(cc(cc2)[N+](=O)[O-])O
• CAS DataBase Reference: 182498-32-4

Description and Uses

CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene α (Gro-α; CXCL1). IL-8 and Gro-α are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB 225002 is a selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 with an IC₅₀ value of 22 nM. SB225002 inhibits neutrophil chemotaxis in response to IL-8 in vitro (IC₅₀ = 20 nM) and blocks neutrophil margination induced by IL-8 in vivo (IC₅₀ = 30 nM). Similarly, SB 225002 reduces neutrophil influx, the production of inflammatory mediators, and tissue damage in TNBS-induced colitis in mice.

SB 225002 is a potent and selective CXCR2 antagonist with the ability to inhibit interleukin IL-8 binding to CXCR2.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HS Code: 2921490090
• Storage Class: 11 - Combustible Solids