BD4818341
N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide , 98% , 432531-71-0
Synonym(s):
MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB328.00 | In Stock |
|
| 10mg | RMB556.00 | In Stock |
|
| 25mg | RMB944.00 | In Stock |
|
| 50mg | RMB1600.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| storage temp. | +2C to +8C |
| solubility | DMSO:100.0(Max Conc. mg/mL);216.7(Max Conc. mM) |
| form | Dark yellow solid |
| color | Light yellow to yellow |
| InChI | 1S/C18H15N5O6S2/c1-29-18-17(19-10-11-20-18)22-31(27,28)14-6-2-12(3-7-14)21-15(24)8-4-13-5-9-16(30-13)23(25)26/h2-11H,1H3,(H,19,22)(H,21,24)/b8-4+ |
| InChIKey | FNPPHVLYVGMZMZ-XBXARRHUSA-N |
| SMILES | [S](=O)(=O)(Nc3ncc[n+H]c3OC)c1ccc(cc1)\N=C(/[O-])\C=C\c2[s]c(cc2)[N+](=O)[O-] |
Description and Uses
Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
