ACetylene-PEG4-biotinconjugate , 95% , 1262681-31-1

CAS NO.：1262681-31-1

Empirical Formula: C21H35N3O6S

Molecular Weight: 457.58

MDL number:

PRODUCT Properties

• Melting point: 55-64 °C
• Boiling point: 707.1±60.0 °C(Predicted)
• Density: 1.158±0.06 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: good in water, DMSO, DCM, DMF
• pka: 13.90±0.40(Predicted)
• form: solid
• color: Off-white to light yellow
• Appearance: White or light grey solid binding

Description and Uses

Biotin-PEG4-alkyne is a click chemistry biotinylation tool. This reagent allows the labeling of azide-containing molecules with biotin via copper-catalyzed click reaction. Biotin-labeled biomolecules can be bound to avidin or streptavidin for further purification and detection.

This structure of biotin alkyne features a long hydrophilic PEG4 linker that separates biotin residue from the target molecule for efficient binding with streptavidin. Its linker also enhances aqueous solubility to facilitate conjugation.

Biotin-PEG4-alkyne may be used for the modification of 4-azidophenylalanine (AzPhe) silk fibroin via bioorthogonal azide–alkyne cycloaddition reaction for developing photopatternable protein material.