(S)-Willardiine , 98% , 21416-43-3
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB580.00 | In Stock |
|
| 25mg | RMB1351.20 | In Stock |
|
| 50mg | RMB2567.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | 2-8°C(protect from light) |
| solubility | 0.1 M NaOH: 7.2 mg/mL |
| form | solid |
| Density | 1.501±0.06 g/cm3(Predicted) |
| pka | 2.12±0.10(Predicted) |
| color | white |
Description and Uses
This simple base occurs in germinatine pea seeds or seedlings. The structure given above has been determined from chemical and s'pectroscopic analysis.
(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM. IC50 value: 44.8 uM(EC50) [1] Target: AMPA/kainate receptor agonist in vitro: The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses [1]. At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% [2]. in vivo: In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists [3].
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H312-H332 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
