N,N-Dimethyl-2,3-bis((Z)-octadec-9-en-1-yloxy)propan-1-amine , 98% , 104162-47-2

Synonym(s):
N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine;1,2-Dioleyloxy-3-(dimethylamino)propane;1,2-Dioleyloxy-3-dimethylaminopropane;DODMA

CAS NO.：104162-47-2

Empirical Formula: C41H81NO2

Molecular Weight: 620.09

MDL number: MFCD22200991

PRODUCT Properties

• Boiling point: 649.7±55.0 °C(Predicted)
• Density: 0.869±0.06 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: Soluble in Ethanol, DMSO, DMF
• pka: 8.65±0.28(Predicted)
• form: Liquid
• color: Colorless to light yellow
• biological source: synthetic
• BRN: 10139013
• InChIKey: GLGLUQVVDHRLQK-WRBBJXAJSA-N
• SMILES: C(N(C)C)C(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC

Description and Uses

1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of liposomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.

DODMA is responsible for the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA useful for silencing disease-causing genes in hepatocytes following i.v. administration.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H302-H315-H319-H331-H336-H351-H361d-H372
• Precautionary statements: P201-P260-P264-P280-P304+P340+P311-P403+P233
• WGK Germany: 3
• Storage Class: 10 - Combustible liquids