3-(2-(Prop-2-yn-1-yloxy)ethoxy)propanoicacid , 97% , 1859379-85-3

CAS NO.：1859379-85-3

Empirical Formula: C8H12O4

Molecular Weight: 172.18

MDL number: MFCD29764323

PRODUCT Properties

• storage temp.: -20°C
• solubility: DMSO: 250 mg/mL (1451.97 mM)
• form: Liquid
• color: Colorless to light yellow
• InChI: 1S/C8H12O4/c1-2-4-11-6-7-12-5-3-8(9)10/h1H,3-7H2,(H,9,10)
• InChIKey: NNWHATPXNWOQKD-UHFFFAOYSA-N
• SMILES: C#CCOCCOCCC(O)=O

Description and Uses

Propargyl-PEG2-acid is a linker consisting of propargyl and carboxylic acid functional groups. In the presence of activators (e.g. EDC, or HATU), the carboxylic acid reacts with primary amine to form a stable amide bond. The propargyl group reacts with azide group in biomolecules to yield a stable triazole linkage.

Propargyl-PEG₂-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG₂-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

Safety

• Symbol(GHS): GHS07,GHS05
• Signal word: Danger
• Hazard statements: H335-H315-H318
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P280-P305+P351+P338-P310
• WGK Germany: WGK 3
• Storage Class: 11 - Combustible Solids