BD8893055
Oct-7-ynoicacid , 97% , 10297-09-3
| Pack Size | Price | Stock | Quantity |
| 100mg | RMB477.60 | In Stock |
|
| 250mg | RMB714.40 | In Stock |
|
| 1g | RMB1777.60 | In Stock |
|
| 5g | RMB3985.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 19°C |
| Boiling point: | 290.64°C (rough estimate) |
| Density | 1.0450 (rough estimate) |
| refractive index | 1.4502 |
| solubility | DMSO: 150 mg/mL (1070.05 mM) |
| form | Liquid |
| pka | 4.74±0.10(Predicted) |
| color | Colorless to light pink |
| Water Solubility | Water: 5 mg/mL (35.67 mM) |
Description and Uses
7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Safety
| Symbol(GHS) |   GHS07,GHS05 |
| Signal word | Danger |
| Hazard statements | H314-H335 |
| Precautionary statements | P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501 |