Fmoc-Arg(Me,Pbf)-OH , 98% , 1135616-49-7

CAS NO.：1135616-49-7

Empirical Formula: C35H42N4O7S

Molecular Weight: 662.8

MDL number: MFCD08064312

PRODUCT Properties

• Density: 1.33
• storage temp.: Store at -15°C to -25°C.
• form: powder
• pka: 3.80±0.21(Predicted)
• Appearance: Off-white to light yellow Solid
• InChIKey: JAUPJPAADXVUGQ-LJAQVGFWSA-N
• SMILES: C(O)(=O)[C@H](CCCNC(NS(C1=C(C)C(C)=C2OC(C)(C)CC2=C1C)(=O)=O)=NC)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

Description and Uses

FMOC-Arg (ME, PBF)-OH is a kind of protected form of arginine. Arginine is double-protected by butyloxycarbonyl (BOC) and 2, 2, 4, 6, 7-pentamethyldihydrobenzofuran-5-sulfonyl (PBF). It is a derivative for introducing mono-methyl-arginine during Fmoc SPPS. Coupling can be carried out using any standard activation method. PBF protecting group can be removed by TFA-mediated cleavage reaction. As a kind of protected amino acid, it is an important intermediate in various fields such as peptide synthesis, asymmetric synthesis, medicinal chemistry as well as polymer chemistry.

Fmoc-?Arg(Me,?pbf)?-?OH can be used as reactant/reagent in design, synthesis and structure-activity relationship of macrocyclic peptidomimetics that bind to WDR5 and block WDR5-MLL protein-protein interaction.