1-Methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine , 97% , 918524-63-7

CAS NO.：918524-63-7

Empirical Formula: C16H26BN3O2

Molecular Weight: 303.21

MDL number: MFCD07437995

PRODUCT Properties

• Melting point: 125 °C
• Boiling point: 435.2±45.0 °C(Predicted)
• Density: 1.10±0.1 g/cm3(Predicted)
• storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
• pka: 8.41±0.31(Predicted)
• form: solid
• color: white
• InChI: InChI=1S/C16H26BN3O2/c1-15(2)16(3,4)22-17(21-15)13-6-7-14(18-12-13)20-10-8-19(5)9-11-20/h6-7,12H,8-11H2,1-5H3
• InChIKey: KVQXFNGVIIPCSX-UHFFFAOYSA-N
• SMILES: N1(C)CCN(C2=NC=C(B3OC(C)(C)C(C)(C)O3)C=C2)CC1

Description and Uses

1-Methyl-4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridin-2-yl]piperazine is used to prepare yrazolopyridine and indazoles as histone lysine methyltransferase EZH2 inhibitors. It is also used to synthesize tetrahydropyrido pyrazines as anaplastic lymphoma kinase inhibitors.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280-P305+P351+P338-P304+P340-P405-P501A
• Hazard Codes: C
• Risk Statements: 22-34
• Safety Statements: 22-26-36/37/39-45
• RIDADR: UN2811
• TSCA: No
• HazardClass: 6.1
• HS Code: 2933998090
• Limited Quantities: 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
• Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)