BD9737255
Mal-peg8-acid , 95% , 1818294-46-0
CAS NO.：1818294-46-0
Empirical Formula: C23H39NO12
Molecular Weight: 521.56
MDL number: MFCD26793771
| Pack Size | Price | Stock | Quantity |
| 100mg | RMB822.40 | In Stock |
|
| 250mg | RMB1224.00 | In Stock |
|
| 1g | RMB3068.80 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 634.6±55.0 °C(Predicted) |
| Density | 1.213±0.06 g/cm3(Predicted) |
| solubility | Soluble in Water, DMSO, DCM, DMF |
| pka | 4.28±0.10(Predicted) |
| form | powder |
| color | White |
| InChI | InChI=1S/C23H39NO12/c25-21-1-2-22(26)24(21)4-6-30-8-10-32-12-14-34-16-18-36-20-19-35-17-15-33-13-11-31-9-7-29-5-3-23(27)28/h1-2H,3-20H2,(H,27,28) |
| InChIKey | KLZPPWOSICDUKQ-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O |
Description and Uses
Mal-PEG8-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Mal-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| HS Code | 2930909899 |
