Home Categories 1-(4-Amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
1-(4-Amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
SDS-US
BD9798455

1-(4-Amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one , 98% , 137977-97-0

CAS NO.：137977-97-0

Empirical Formula: C18H17ClN2O2

Molecular Weight: 328.79

MDL number:

EINECS: 1592732-453-0

Pack Size Price Stock Quantity
250mg RMB77.60 In Stock
1g RMB208.00 In Stock
5g RMB735.20 In Stock
25g RMB2572.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 186-189°C
Boiling point: 565.4±50.0 °C(Predicted)
Density  1.320
storage temp.  -20°C Freezer
solubility  DMSO (Slightly), Methanol (Slightly)
pka 2.28±0.10(Predicted)
form  Solid
color  Off-White to Pale Yellow
InChI InChI=1S/C18H17ClN2O2/c1-11-9-13(20)5-6-14(11)18(23)21-8-2-3-17(22)15-10-12(19)4-7-16(15)21/h4-7,9-10H,2-3,8,20H2,1H3
InChIKey FLJCJPKXJWRZJB-UHFFFAOYSA-N
SMILES N1(C(=O)C2=CC=C(N)C=C2C)C2=CC=C(Cl)C=C2C(=O)CCC1

Description and Uses

1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one is an intermediate used in the synthetic preparation of Tolvaptan (T536650), a selective nonpeptide arginine vasopressin V2 receptor antagonist.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P280

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