Maitansine , 98+% , 35846-53-8

CAS NO.：35846-53-8

Empirical Formula: C34H46ClN3O10

Molecular Weight: 692.2

MDL number:

EINECS: 252-754-7

PRODUCT Properties

• Melting point: 183.5-184℃
• alpha: D26 -145° (c = 0.055 in chloroform)
• Boiling point: 895.1±65.0 °C(Predicted)
• Density: 1.1049 (rough estimate)
• refractive index: 1.6000 (estimate)
• storage temp.: Store at -20°C
• solubility: DMF: 1 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
• form: A solid
• pka: 9.82±0.70(Predicted)
• color: white to beige
• optical activity: -14526 (c 0.055, CHCl3)
• Stability: Light Sensitive
• InChIKey: WKPWGQKGSOKKOO-YHBUUTGONA-N

Description and Uses

This novel ansa macrolide alkaloid occurs in a number of May tan us species. The structure given has been elucidated from chemical and spectroscopic data. In low doses (25-50 mcg/kg), maytansine prolonged the survival of mice bearing vincristine-sensitive P388 leukemia but not those bearing vincristine-resistant tumour lines. In vitro, it suppressed the growth of U21 0, LSl78Y and P388 leukemia cells with ED₅₀ of 2 X 10^-9 , 1.5 X 10^-9 and 6 X 10^-10M respectively and elevated the mitotic index in L 121 0 cells. From labelling studies it was shown that the alkaloid inhibited DNA formation by P388 cells to a greater extent than RNA and protein synthesis. Maytensine did not inhibit RNA polymerase from Escherichia coli at levels as high as 1 X 10^-4M.

Antineoplastic.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300+H310-H331
• Precautionary statements: P261-P262-P264-P270-P271-P280-P301+P310-P321-P330-P302+P352-P304+P340-P311-P361+P364-P403+P233-P405-P501
• Toxicity: LD50 in rats (mg/kg): 0.48 s.c. (Mugera, Ward)