tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate , 95% , 951127-25-6

CAS NO.：951127-25-6

Empirical Formula: C16H19F2NO4

Molecular Weight: 327.32

MDL number: MFCD20926096

PRODUCT Properties

• Boiling point: 433.4±45.0 °C(Predicted)
• Density: 1.25±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• pka: 11.00±0.40(Predicted)
• Appearance: White to off-white Solid
• InChI: InChI=1S/C16H19F2NO4/c1-16(2,3)23-15(21)19-13-7-10(20)8-22-14(13)11-6-9(17)4-5-12(11)18/h4-6,13-14H,7-8H2,1-3H3,(H,19,21)/t13-,14+/m0/s1
• InChIKey: OTCULXVRRSCLLI-UONOGXRCSA-N
• SMILES: C(OC(C)(C)C)(=O)N[C@H]1CC(=O)CO[C@@H]1C1=CC(F)=CC=C1F

Description and Uses

N-[(2R,3S)-2-(2,5-Difluorophenyl)tetrahydro-5-oxo-2H-pyran-3-yl]carbamic Acid 1,1-Dimethylethyl Ester is a useful synthetic intermediate in the synthesis of Omarigliptin (O633100); a potent and selective dipeptidyl peptidase 4 (DPP-4) inhibitor used for the treatment of type 2 diabetes.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338