4-(Dimethylamino)antipyrine , 98+ , 58-15-1

Synonym(s):
4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one;Aminopyrine

CAS NO.：58-15-1

Empirical Formula: C13H17N3O

Molecular Weight: 231.29

MDL number: MFCD00003142

EINECS: 200-365-8

PRODUCT Properties

• Melting point: 107-109 °C(lit.)
• Boiling point: 373.38°C (rough estimate)
• Density: 1.0744 (rough estimate)
• refractive index: 1.6140 (estimate)
• storage temp.: Refrigerator
• solubility: DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
• pka: pKa 5.0 (Uncertain)
• form: Crystalline Powder, Crystals and/or Chunks
• color: Off-white to brownish
• Water Solubility: 5.55 g/100 mL
• Sensitive: Air & Light Sensitive
• Merck: 14,474
• Stability: Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive. Degrades under the action of mild oxidizing agents in the presence of moisture or water.
• InChIKey: RMMXTBMQSGEXHJ-UHFFFAOYSA-N
• CAS DataBase Reference: 58-15-1(CAS DataBase Reference)
• NIST Chemistry Reference: Aminopyrine(58-15-1)
• EPA Substance Registry System: Aminopyrine (58-15-1)

Description and Uses

Aminopyrine is used as an antipyretic and analgesic drug. It belongs to the pyrazolone derivatives having a most toxic and most dangerous analgesic effect and it is a non-narcotic drug. Due to strong adverse effects, its single medicine preparation is gradually replaced by compound preparation.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301-H315-H319-H335
• Precautionary statements: P261-P264-P270-P301+P310-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38-21/22
• Safety Statements: 26-36-36/37/39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: CD2625000
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29331190
• Hazardous Substances Data: 58-15-1(Hazardous Substances Data)
• Toxicity: LD50 orally in rats: 1.7 g/kg (Hart)