5-epi EMtricitabine , 0.95 , 145986-26-1

CAS NO.：145986-26-1

Empirical Formula: C8H10FN3O3S

Molecular Weight: 247.25

MDL number:

Update time: 2023-04-23

PRODUCT Properties

Melting point:	>166°C (dec.)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
color	White to Pale Beige
Stability:	Hygroscopic
InChI	InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6-/m1/s1
InChIKey	XQSPYNMVSIKCOC-PHDIDXHHSA-N
SMILES	C1(=O)N([C@@H]2O[C@@H](CO)SC2)C=C(F)C(N)=N1

Description and Uses

5-epi Emtricitabine is an epimer of Emtricitabine (E525000), a nucleoside reverse transcriptase inhibitor approved for treatment of human immunodeficiency virus (HIV) 1, and also has antagonistic activity against the hepatitis B virus. 5-epi Emtricitabine is also used as a reagent for the synthesis of β-L-(2R,5S)- and α-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential HIV agents.

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