10-formyldihydrofolate , 90%+ , 28459-40-7

CAS NO.：28459-40-7

Empirical Formula: C20H21N7O7

Molecular Weight: 471.43

MDL number:

PRODUCT Properties

• Density: 1.67±0.1 g/cm3(Predicted)
• solubility: Aqueous Acid (Slightly), Aqueous Base (Slightly)
• pka: 3.38±0.10(Predicted)
• form: Solid
• color: Orange to Very Dark Brown
• Stability: Hygroscopic, Temperature Sensitive
• InChIKey: UXFQDXABPXWSTK-VHLFKADZNA-N
• SMILES: O=C1N=C(N)NC2NCC(CN(C3C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=3)C=O)=NC1=2 |&1:19,r|

Description and Uses

10-Formyl-7,8-dihydrofolic acid is a novel folate found in methotrexate-treated cells. 10-Formyldihydrofolate (H2folate) has not been found as a component of intracellular folates in normal tissues but has been identified in the cytosol of methotrexate (MTX)-treated MCF-7 breast cancer cells and normal human myeloid precursor cells.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H317-H334
• Precautionary statements: P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501